2021 Fiscal Year Final Research Report
Study for the functional role of corticosteroids and its regulatory mechanism in oogenesis
| Project/Area Number |
19K06365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 副腎皮質ホルモン / 卵巣機能 / 卵子形成 / 黄体化 |
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| Outline of Final Research Achievements |
The presence of corticosteroid system (i.e., production, reception, action) and its regulatory mechanism were investigated in the bovine ovary and oocyte/early embryo. The results showed that, 1) ovarian tissues and oocyte are not only constantly exposed to adrenal derived corticosteroids (i.e., glucocorticoid and mineralocorticoid) but also able to activate/inactivate them locally, 2) these tissues and cells express receptors for glucocorticoid and mineralocorticoid and through which, corticosteroids regulate ovarian functions, such as promoting luteinaization and supporting oogenesis, 3) the ovarian regulatory system of corticosteroids cross-talks with that of sex steroids (i.e., progesterone) and elaborately regulates ovarian functions. These results indicate that the ovarian corticosteroid system is well integrated into the ovarian physiology.
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| Free Research Field |
繁殖生物学
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| Academic Significance and Societal Importance of the Research Achievements |
過去に多くの研究が積み重ねられてきた性ステロイドホルモンとは違い、副腎皮質ホルモンの生殖生理への関与についてはほとんど明らかにされていない。本研究では恒常性の維持に関与している副腎皮質ホルモンが、周期的な生殖のリズムを生み出す性ステロイドとクロストークしながら卵巣機能調節に関与していることや、卵形成に関与している可能性を示唆した。これらの知見は今まで別々に扱われてきた生殖と生存のためのシステムを結びつけ、生理学に新しい見識を加えると共に、例えばストレス性の不妊などに対処する生殖医療のために必要となる基礎知識を提供すると考える。
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