2021 Fiscal Year Final Research Report
The inhibitory mechanism of amyloid fibrosis by peptides from hen egg proteins and prevention effects against diseases.
| Project/Area Number |
19K06376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Kyushu Nutrition Welfare University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
日下部 宜宏 九州大学, 農学研究院, 教授 (30253595)
阿部 義人 国際医療福祉大学, 福岡保健医療学部, 教授 (60315091)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 認知症 / 糖尿病 / アミロイド線維 / 糖代謝酵素 / ポリオール経路 / 鶏卵ペプチド / カラザ |
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| Outline of Final Research Achievements |
Diseases such as dementia and diabetes are increasing due to the aging society and changes in lifestyle. As one of methods for preventing diseases, it is necessary to improve the eating habits, and the ingredients taken every day are required to be effective in preventing diseases. Among foods, eggs are cheap and nutritious foods, and are expected to have the preventing functions for diseases.
In this study, whether peptides derived from hen egg protein were examined to be suppressive effective against the formation of amyloid fibrils. In addition, the preventive effects for diabetes were investigated. The chalaza peptides have the effect of inhibiting amyloid fibril formation and were expected to be effective in many amyloid diseases involving amyloid fibrils. Peptides derived from egg white and eggshell membranes showed inhibitory effects on glycolytic enzymes and polyol pathway enzymes. Therefore, egg peptides are expected to be useful for the prevention of such diseases.
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| Free Research Field |
食品化学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会や生活習慣の変化により認知症や糖尿病などの疾患が増加しており、社会的問題化しており、これを予防する方法として食生活の改善が必要とされ、毎日摂取する食品素材に疾患予防効果があるものが求められる。鶏卵は安価で栄養価の高い食品であり、今回、見出した鶏卵タンパク質由来のペプチドが認知症や糖尿病の予防に有効であることが確認された。カラザペプチドはアルツハイマー病などの原因となるアミロイド線維の形成を抑制し、また卵白および卵殻膜ペプチドは糖代謝酵素や糖尿病合併症に関わる酵素を阻害した。今後、ヒト介入実験などの研究が進み、鶏卵ペプチドの有効活用が期待される。
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