2021 Fiscal Year Final Research Report

Basic validation of the efficacy of insoluble hyaluronic acid for the development of new prophylactic agents for postoperative contracture of knee joints

Research Project

PDF

Project/Area Number	19K06411
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 42020:Veterinary medical science-related
Research Institution	Obihiro University of Agriculture and Veterinary Medicine (2020-2021) University of Tsukuba (2019)
Principal Investigator	Uemura Akiko 帯広畜産大学, 畜産学部, 准教授 (60823721)
Co-Investigator(Kenkyū-buntansha)	田中綾東京農工大学, (連合)農学研究科(研究院), 教授 (70334480)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	術後癒着 / ヒアルロン酸 / 膝関節
Outline of Final Research Achievements	In the first year, there were significant differences between the experimental and control groups in thigh length, above-knee length, and ROM.The results of the second year showed no significant differences between the experimental and control groups in above-knee length, below-knee length, and ROM, but significant differences were found in thigh length between the experimental and control groups.In the final year, there were no significant differences between the experimental and control groups in below-knee length, but significant differences in thigh length, above-knee length, and ROM between the experimental and control groups.However, there were significant differences in thigh length, above-knee length, and ROM between the experimental and control groups. These results suggest that the use of insoluble hyaluronic acid membrane inside and outside rat joints may be effective in reducing disuse atrophy of the perifemoral musculature.
Free Research Field	獣医外科学
Academic Significance and Societal Importance of the Research Achievements	膝関節手術は人工膝関節置換術だけでも国内で年間 80,000件を超えており、術後高率に関節拘縮が生じる。関節拘縮の主な治療法は、関節鏡を用いた癒着の剥離手術とリハビリテーション等の理学療法であるが、患者が正常な膝関節機能を再び得るのは容易ではない。最も重要なことは発症後の治療ではなく、術後の膝関節拘縮そのものの予防が求められている。本研究ではラットの膝関節手術に不溶化ヒアルロン酸を使用することで、術後の膝関節可動域低下や大腿部長低下を有意に低減させる可能性が示唆された。今後の膝関節術後拘縮予防に向けて、学術的にも社会的にも1つの有用な知見になり得ると考えられる。