2022 Fiscal Year Final Research Report
Promotion of studies on Keterah orthonairovirus
| Project/Area Number |
19K06414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | keterah orthonairovirus / Issyk-Kul熱 / Soft tick bunyavirus / 治療 / アビガン / 抗体 |
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| Outline of Final Research Achievements |
We compared virological characteristics of two orthonairoviruses, Issyk-Kul virus which causes Issyk-Kul disease, and soft tick bunyavirus which was found in Japan and is similar with Issyk-Kul virus.
Followings were revealed; no apparent growth difference in 8 mammalian cell lines, partial cross-reactivities of anti-sera, no apparent pathogenicity difference in IFNAR1-KO mice, and monoclonal antibodies to the viral envelope and Avigan were effective in treatment in mouse model.
These findings support further therapeutic development against Issyk-Kul and related diseases because therapeutic candidates were found, whereas we could not exclude a possibility that soft tick bunyavirus in Japan causes a disease in humans.
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| Free Research Field |
ウイルス学
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| Academic Significance and Societal Importance of the Research Achievements |
日本で発見されたsoft tick bnyavirusとIssyk-Kul熱をおこすIssyk-Kulウイルスはウイルス学的に非常に似ていた。Issyk-Kul熱は日本で発生しておらず、不明熱の原因としてsoft tick bnyavirusが少ないながらある可能性が考えられた。単クローン抗体やインフルエンザ薬のアビガンがマウスモデルで治療効果を示したことから、これらの開発を進めることでsoft tick bnyavirus（や関連ウイルス）による感染症あるいはIssyk-Kul熱の国内侵淫に備えることができる。
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