2021 Fiscal Year Final Research Report
Effect of fatty acid quality on sperm motility
| Project/Area Number |
19K06446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42030:Animal life science-related
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 精子 / 鞭毛運動 / CatSper / PPARγ / 重炭酸イオン |
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| Outline of Final Research Achievements |
Recently, infertility caused by nutritional abnormalities such as obesity and undernutrition has become a problem in many animals, from livestock to humans. This study examined the effect of long-chain fatty acids on mouse sperm motility. We found that unsaturated-fatty acids increase sperm flagellar motility not as metabolic energy or a membrane component, but through the nuclear receptor PPARγ. Furthermore, the involvement of bicarbonate ion and Ca2+ influx into sperm via CatSper channels were involved in the motor activation.
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| Free Research Field |
繁殖学・生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研成果の学術的意義は長鎖和脂肪酸が代謝エネルギーや膜の構成成分としてではなく、シグナル分子として精子の運動性を制御する生理的メカニズムについて明らかとした点にある。また、近年、世界的問題となっている肥満や低栄養が生殖に与える影響について新たな知見を加えることになる点が本研究の社会的意義である。
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