2021 Fiscal Year Final Research Report
Elucidation of epigenetic mechanisms that memorize inter-tissue communication
| Project/Area Number |
19K06608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43050:Genome biology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 脂肪組織 / 交感神経系 / 視床下部 / エピゲノム / 代謝制御 / 摂食制御 |
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| Outline of Final Research Achievements |
The onset of lifestyle-related diseases can be considered to be due to abnormal interactions between tissues mediated by environmental cues. From the analysis of epigenome-modifying enzyme (JMJD1A) knockout mice, this study revealed that 1) epigenome changes are important for inducing the expression of thermogenic genes in white adipose tissue under cold stimulation and 2) the sensitivity of the hypothalamus to leptin secreted from adipose tissue is regulated by the epigenome-modifying enzyme. This study elucidated a part of the inter-tissue communication and epigenome regulation involved in the onset of lifestyle-related diseases.
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| Free Research Field |
ゲノム生物学
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| Academic Significance and Societal Importance of the Research Achievements |
エピゲノムは外的環境に依存して後天的に書き換えられる遺伝情報である。生活習慣や食習慣などの環境要因はエピゲノムとして細胞に記憶され、脂肪を蓄積あるいは燃焼しやすい体質を作ったり、食欲の制御に働いていると考えられる。本研究では、脂肪を燃焼する体質がエピゲノムによって制御されること、エピゲノム修飾酵素が食欲の抑制に働いていることを明らかにした。本研究で得られた研究成果は、生活習慣病の予防・治療への足がかりとなる。
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