2021 Fiscal Year Final Research Report
Study on the mechanism that regulates asymmetric peeling involved in the separation of germ layer fates
| Project/Area Number |
19K06694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 44020:Developmental biology-related
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 胚葉運命 / mRNA非対称分配 / 細胞分裂 / 核移動 |
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| Outline of Final Research Achievements |
The details of the process of segregation of germ layer fates among embryonic cells are unknown in most animals. Using a primitive chordate, Halocynthia roretzi, we previously showed that the separation of embryonic fates is mediated by the asymmetric partitioning of mRNA which encodes a transcription factor called Not from mesoendoderm mother cell to the daughter mesoderm cell. In the present study, we showed that the difference in cell cycle length between mesoendoderm cells and the adjacent cell regulates the position of the cleavage plane in the mesendoderm cell via mesoendoderm cell deformation.
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| Free Research Field |
発生生物学
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| Academic Significance and Societal Importance of the Research Achievements |
臓器の再生には、ES, iPSなどの細胞から適切な数・種類の分化した細胞を適切な位置に作ることが重要である。しかし、細胞分化の初期過程にある、胚葉の形成を細胞レベルで制御することは困難である。今回の研究は、胚葉形成過程にある細胞集団内にある、細胞周期のズレが中胚葉と内胚葉の適切な形成に重要であることを示しており、臓器再生の際に、幹細胞からの胚葉形成を制御するための基盤を提供する研究であると考えられる。
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