Elucidation of host searching behavior related with nematode evolution

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K06811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 45030:Biodiversity and systematics-related
• Research Institution: University of Miyazaki
• Principal Investigator: Tanaka Ryusei 宮崎大学, 医学部, 助教 (70723550)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 宿主探索 / 線虫

Outline of Final Research Achievements

To understand the nematode`s host searching systems, we tried to identify the receptors for the host chemicals and clarify the details of the reactions for the host vibrations. As the results, we identified the candidates of the receptors which detect the host chemicals. Additionally, the nematode which can react the host chemicals was transferred effectively than other nematode species. Nematode detected the vibrations via the receptors which exist the surface of its whole body. Nematode reacted sensitively around the host`s vibration ranges. Furthermore, it was suggested that nematode used the information of vibrations not only for the host searching behavior but also for the escape from large animal stamps.

Free Research Field

線虫学

Academic Significance and Societal Importance of the Research Achievements

本研究では、線虫において、宿主の匂いを受容する受容体の候補群が得られた。これを基に、最終的な匂い受容体の同定につながる。また、宿主の匂いを受容する線虫種の方が、その他の線虫種より効率よく餌から餌へ運ばれており、この現象が進化の原動力の一つになっている可能性が示唆された。この情報と比較ゲノム等により、進化学の新たな知見が得られると考えている。また、本研究で明らかとなった線虫の振動受容の知見を発展されることにより、寄生性の線虫の防除などへの応用が期待される。