2022 Fiscal Year Final Research Report
Species and genetic diversity of the azole-resistant medical fungi in the Izu and Bonin Islands
Project/Area Number |
19K06826
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 45030:Biodiversity and systematics-related
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Research Institution | Nihon University |
Principal Investigator |
HIROSE Dai 日本大学, 薬学部, 教授 (20513922)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | アスペルギルス症 / 薬剤耐性 / 抗真菌薬 / 多様性 / 集団遺伝 / 分類 / 島嶼 |
Outline of Final Research Achievements |
The species diversity and distribution of Aspergillus sect. Fumigati in outdoor environments of Izu and Ogasawara Islands were investigated. Seven Aspergillus sect. Fumigati species were identified. The occurrence frequency of A. fumigatus was higher in forest sites on the islands, except for Ogasawara Islands, whereas that of species other than A. fumigatus was higher in bare land and grassland sites on all islands. Considering other Aspergillus species, A. felis showed high occurrence frequency on islands between Izu-oshima and Shikinejima, A. pseudoviridinutans on islands between Kozushima and Hachijojima, and A. udagawae on Ogasawara Islands. Genome-wide genotyping of A. felis, A. psedoviridinutans, and A. udagawae was performed by GRAS-Di analysis. STRUCTURE analysis based on genotype data revealed multiple clusters based on genetic information in all species, but no clear genetic differentiation among islands.
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Free Research Field |
真菌学
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Academic Significance and Societal Importance of the Research Achievements |
真菌症起因菌の野外環境における生態学的特性に関する情報は世界的にみても殆どない。そのため、本研究で得られた知見は真菌の多様性科学のみならず疫学や環境医学においても重要なものであると考えられる。超高齢化社会を迎えると共に抗癌剤治療やHIV感染などにより免疫力の低下した患者が増加傾向にあることを考えると、真菌症の罹患者数は今後急激に増大すると予想される。本研究の成果はこの様な状況に備えるための生物学的な基礎情報を提供することから社会的意義は大きいと思われる。
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