Synthesis of chiral phosphorous compounds utilizing sulfur

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Hirashima Shin-ichi 東京薬科大学, 薬学部, 准教授 (80642264)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 光学活性有機リン化合物 / 不斉ヒドロホスフィニル化反応

Outline of Final Research Achievements

Optically active organophosphorus compounds are remarkably attractive because they play important synthetic role in metal catalysis and organocatalysis. However, the lack of diversity in the asymmetric synthesis method has delayed research on the usefulness of organophosphorus compounds. The purpose of this study is to establish a new efficiency construction method for chiral organic phosphorus compounds that utilize the characteristics of sulfur elements. By using a secondary phosphine sulfide introduced with a sulfur atom, an asymmetric hydrophosphinylation reaction with a nitroalkene was successful. The usefulness of the product was also clarified.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

硫黄元素の特性を活かし、光学活性な有機リン化合物を合成する化学技術は、今後の精密有機合成、医薬品合成に必要不可欠な配位子や触媒を創製する方法論となりえます。この度の研究助成金で開発された光学活性有機リン化合物の新たな機能性が見出され、本分野の発展につながることが期待されます。