Estimated intake of benzotriazole UV stabilizers and risk assessment of infants

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Setsunan University
• Principal Investigator: Nakao Teruyuki 摂南大学, 薬学部, 准教授 (20288971)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ベンゾトリアゾール系紫外線吸収剤 / 母乳 / 乳児

Outline of Final Research Achievements

Benzotriazole UV stabilizers (BUVA) are widely used as UV light filters and stabilizers in cosmetics, skin creams, and body lotions and as corrosion inhibitors in building materials, automobile components, and automotive antifreeze cooling systems. Some of these BUVA have been reported to possess hepatoxicity and endcrine disruption. On the other hand, the human contamination level and the contamination route by BUVA are unknown. In this study, I attempted to elucidate the contamination level of human breast milk and to investigate the sontamination route.
BUVA were detected in all milk samples, with a maximum concentration of 6.57 ng/mL. The main components were UV320, UV329 and UV9. The composition of these chemicals were similar to those of diet and indoor air samples. These results suggest that dietary and atmospheric BUVA are transferred to breast milk.

Free Research Field

衛生薬学

Academic Significance and Societal Importance of the Research Achievements

ベンゾトリアゾール系紫外線吸収剤 (BUVA) は、化粧品などに広く使われている。BUVAは肝毒性を持つことが報告されている。一方で、BUVAによる人体汚染やその曝露経路については明らかにされていない。本研究では、母乳を調査と母乳提供者が摂取した食事及び生活環境大気も同時に調査することにより、BUVAの汚染実態を解明し、曝露経路の究明を行った。すべての母乳からBUVAが検出され、平均濃度は42.5 ng/g, lipidであり、その濃度範囲は12.8～159 ng/g, lipidであった。母乳中の主成分は、UV320であることが判明し、主に食事の影響を受けていることが明らかとなった。