Development of real-time monitoring devices and elucidation of individual differences in the pathogenesis of headache

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47040:Pharmacology-related
• Research Institution: Kumamoto University
• Principal Investigator: Kurauchi Yuki 熊本大学, 大学院生命科学研究部(薬), 助教 (70631638)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 頭痛 / 脳血流 / 脳温 / 性差 / 気象病 / 低気圧

Outline of Final Research Achievements

We developed devices that can measure cerebral blood flow (CBF) and brain temperature in real-time under freely moving conditions, and found that CBF in mice increases while brain temperature decreases under low atmospheric pressure conditions. When mice were returned to the normal atmospheric pressure environment, both CBF and brain temperature recovered. Although there was no gender-difference in CBF, the decrease in brain temperature was more pronounced in male mice than in female mice. These findings provide basic insight into sex difference in the pathogenesis of headaches.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

気圧変動によって脳血流ならびに脳温が変動することに初めて成功した点は, 頭痛病態の解明に与えるインパクトが大きい. さらに脳温変化に性差があることも明らかにしており, 「脳温」が頭痛病態発症の性差を解明するために有効な生理パラメーターとなり得る.