2022 Fiscal Year Final Research Report
Elucidation of the treatment mechanism of yokukansan for emotional abnormality of offspring induced by stress exposure during pregnancy
| Project/Area Number |
19K07137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
辻 稔 国際医療福祉大学, 薬学部, 教授 (70297307)
黒川 和宏 国際医療福祉大学, 薬学部, 講師 (30454846)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 胎生期ストレス / 抑肝散 / エピジェネティクス / 不安 / 漢方処方 / ドパミン / セロトニン |
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| Outline of Final Research Achievements |
The execive stress exposure during pregnancy has been reported to have an impact on the mental development of the child, according to clinical studies. In the present study, we created a prenatal stress exposure mouse model and attempted to elucidate its pathophysiological characteristics. As a result, we discovered that abnormalities in the epigenetic control mechanism based on histone modifications in the brain during the prenatal period may be involved in the development of mental disorders in offspring caused by prenatal stress. Furthermore, we examined the effects of Yokukansan, a traditional Japanese herbal medicine, to both the mother and offspring, on the emotional disorders induced by prenatal stress stimuli. The results showed that the anxiety like behavior induced by prenatal stress stimuli was improved by treatment with Yokukansan to the mother and offspring together, suggesting the involvement of changes in the monoamine neurons in the therapeutic mechanism.
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| Free Research Field |
神経精神薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた知見は、妊娠期における強度なストレス曝露の危険性について警鐘を鳴らすものであり、妊婦のメンタルヘルスに対する意識向上につながると考える。さらに、小児に対して使用実績のある抑肝散の母仔同服の治療効果を実証したことから、妊娠期ストレスが惹起する子の精神発達に対する幼児および小児期における安全性の高い薬物治療の提案につながり、極めて社会的に意義深い研究成果であると考える。さらに、生化学的知見の累積により、エピジェネティクス制御機構やモノアミン神経系の機能変化に起因する可能性を見出し、そのエビデンス構築がなされたことは学術的意義も高いと考える。
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