2021 Fiscal Year Final Research Report
Understanding the changes of constituents in Kampo formula among the process of decoction related with the efficacy
| Project/Area Number |
19K07144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 漢方 / 煎出 / 含有成分 / 化学変化 |
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| Outline of Final Research Achievements |
To confirm the changes of constituents in Kampo formula among the process of decoction related with the efficacy, 21 crude drugs frequently employed for mixed powder or pills of Kampo formula were extracted with hot-water or methanol, respectively. The ingredients of each extract were analyzed by reversed-phase (RP) HPLC comparing with the authentic samples from each crude drag and identified the difference between hot-water and methanol extract. Based on the data, six Kampo formula (tokishakuyakusan, kamishoyosan, goreisan, yokukansan, keishibukuryogan, hachimijiogan) also extracted with hot-water or methanol and analyzed by RP-HPLC and compared the changes the ingredients of the extracts.
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| Free Research Field |
天然物化学
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| Academic Significance and Societal Importance of the Research Achievements |
漢方処方のうち散剤や丸剤は，本来は粉砕した生薬をそのまま混合あるいは成形して用いるが，現在の医療用漢方製剤ではすべて熱水抽出されたエキスを製剤化したものが用いられている．生薬の熱水抽出物では生薬に含まれる高極性化合物のみが溶出していること，及び熱処理の過程で含有成分の分解が想定されるが，その詳細についての検討は乏しい現状がある．そのため，まず各生薬の熱水抽出物の成分分析を行い，そこで得られた情報を基に漢方処方の熱水抽出物とメタノール抽出物の成分分析及び成分比較を行うことで，漢方の薬効理解のための基礎的な資料とすることを目的とする．
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