2021 Fiscal Year Final Research Report
Analysis of the effect of drugs affecting the community composition in the intestinal microflora on the absorption of food allergens and the development of allergy
| Project/Area Number |
19K07164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
Yokooji Tomoharu 広島大学, 医系科学研究科(薬), 准教授 (70389120)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 食物アレルギー / 抗菌薬 / 腸内細菌 / 感作 |
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| Outline of Final Research Achievements |
The prevalence of food allergy has increased in Japan. Some epidemiological studies have showed that changes in community composition in the intestinal microflora might cause the development of allergic diseases. In this study, we examined the effect of antibiotics including vancomycin, ampicillin and kanamycin on the community composition in the intestinal microflora and the sensitization to egg white allergen, ovalbumin. As the results, oral administration of vancomycin, ampicillin and kanamycin altered the community composition in the intestinal microflora partly and decreased the sensitization of ovalbumin in the rat model.
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| Free Research Field |
医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果では、抗菌薬の服用による腸内細菌叢の変化とアレルギー疾患の増加との関連性を明確に示すことができなかった。一方で、抗菌薬の服用によりOVAの感作は減少傾向を示したことから、ラットモデルにおいて抗菌薬の服用により変動した細菌種を網羅的に解析することで、アレルギー疾患の予防に有用な知見が得られる可能性がある。抗菌薬の使用とアレルギー疾患の発症との関連性を明らかにすることで、食物アレルギーの予防や新規治療法の開発に手がかりが得られるものと期待される。
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