Elucidation of novel pathogenesis of polycystic kidney disease using an integrative approach

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48030:Pharmacology-related
• Research Institution: Mie University
• Principal Investigator: Nishimura Yuhei 三重大学, 医学系研究科, 教授 (30303720)
• Co-Investigator(Kenkyū-buntansha): 白水 崇 三重大学, 医学系研究科, 助教 (00582678) ; 稲垣 昌樹 三重大学, 医学系研究科, 教授 (30183007)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 嚢胞腎 / 脳出血 / 一次線毛 / ゼブラフィッシュ / ドラッグリポジショニング

Outline of Final Research Achievements

Polycystic kidney disease is a hereditary disease in which numerous cysts occur in the kidneys, eventually leading to renal failure. Although therapeutic agents that suppress the progression of pathological conditions have been used, not all patients have indications for the drugs. Therefore, it is important to elucidate the pathological mechanism of polycystic kidney disease in more detail and to find new therapeutic target molecules. In this study, we focused on the primary cilia closely associated with the pathophysiology of polycystic kidney disease. We were able to obtain results that could lead to the elucidation of a new pathological mechanism in polycystic kidney disease.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

多発性嚢胞腎では脳出血のリスクが高くなることが臨床的に知られているが、そのメカニズム関しては不明な点が多い。本研究ではゼブラフィッシュにおいて脱ユビキチン化酵素USP8の機能が障害されると、嚢胞腎と脳出血が出現することを見出した。このメカニズムをより詳細に解析することにより、多発性嚢胞腎の病態理解の深化や、新たな治療薬開発につながることが期待できる。