Elucidation of the mechanism of endometrial cancer transformation mediated by nuclear pore complex factor

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07398
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49010:Pathological biochemistry-related
• Research Institution: Kanazawa University
• Principal Investigator: Kobayashi Akiko 金沢大学, 新学術創成研究機構, 特任助教 (00345662)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 核膜孔複合体 / ヌクレオポリン

Outline of Final Research Achievements

The nuclear pore complex existing in the nuclear membrane is a huge complex composed of about 30 kinds of proteins called nucleoporins and is responsible for the transport of molecules between the nucleus and the cytoplasm. RAE1 is one of the nucleoporins and controls the nuclear export of mRNA. It was reported that RAE1 was highly expressed in various cancers and involved in the malignant transformation of cancers. We found that there is a correlation between the malignant transformation of cancer and the expression level of RAE1 in endometrial cancer. It is suggested that RAE1 switches partner molecules and controls exporting mRNA depend on malignancy.

Free Research Field

細胞分子生物学

Academic Significance and Societal Importance of the Research Achievements

研究代表者は、子宮内膜がんにおいて核膜孔複合体因子RAE1の発現がグレード依存的に上昇していること、がんの悪性化に伴いRAE1が相互作用分子を変えていることを見出した。これらのことから、RAE1が将来的に子宮内膜がんの悪性化のマーカーとなりうること、RAE1の発現制御によりがんの悪性化を防ぐ可能性が示された。