2021 Fiscal Year Final Research Report
Development of techniques to detect necroptosis
| Project/Area Number |
19K07399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49010:Pathological biochemistry-related
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| Research Institution | Toho University (2020-2021)
Osaka University (2019) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 細胞死 |
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| Outline of Final Research Achievements |
Necroptosis is the regulated necrosis that is induced in response to the stimulation with cytokines such as tumor necrosis factor, and components of bacteria and viruses. Although various regulatory molecules have been identified in past studies, the molecular mechanism underlying necroptosis remains unknown. In addition, development of tools or methods to detect necroptotic cells is needed.
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| Free Research Field |
病態医化学
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| Academic Significance and Societal Importance of the Research Achievements |
ネクロプトーシスが数多くの感染性・非感染性炎症性疾患の病態に関わっていることが報告されており、これらの疾患に対する治療の有用な標的になると期待されている。本研究で開発された手法を用いて分子機構の詳細を明らかにし、また、生体内でのネクロプトーシスの検出法の確立につなげることで、様々な炎症性疾患に対する新たな治療法の開発につながると期待される。
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