2021 Fiscal Year Final Research Report
Analyses of malignant mechanisms via abnormality of novel multifunctional tricellular junction molecules in cancer cells
| Project/Area Number |
19K07464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49020:Human pathology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
幸野 貴之 札幌医科大学, 医学部, 講師 (10374563)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ３細胞間タイト結合分子 / Angulin-1/LSR / claudin-2 / EGFシグナル / TGF-betaシグナル / HDACシグナル / 癌悪性化 / HDAC阻害剤 |
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| Outline of Final Research Achievements |
Multifunctional tricellular junction molecule angulin-1/LSR maintains the epithelial barrier and induces stability of the collecting cells. Its expression contributes to the malignancy of cancer cells via the binding effects with various functional molecules at tricellular contacts. We performed a multilateral analysis for the regulatory mechanisms and the roles LSR/ASPP2/PAR3/YAP complex proteins in normal human cells and cancer. As result, in various cancer cells, angulin-1/LSR is regulated via multiple intercellular signaling and prevents the malignancy.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、多機能新規３細胞間タイト結合分子angulin-1/LSRの癌細胞における発現調節機構および役割が解明できただけでなく、COVID-19感染を始めとして炎症などの重症化疾患における役割の解明さらに、治療効果のある既存および新規物質のスクリーニングにも役に立つと考えられた。
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