2021 Fiscal Year Final Research Report
Mechanism of environmental response and micro-colony induction in uropathogenic E. coli
| Project/Area Number |
19K07533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49050:Bacteriology-related
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 尿路感染症 / 薬剤耐性 / 病原性 / バイオフィルム / 環境応答 / 発現制御 / 抗菌薬 |
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| Outline of Final Research Achievements |
Urinary tract infection is one of the most common infectious diseases. Uropathogenic E. coli is a major pathogen that causes urinary tract infection, and it internalizes bladder and kidney epithelial cells. This bacterium colonizes within the host cells, which enables to establish and sustain the infection by evading from antimicrobial agents and host immune systems. In this study, we found that extracellular cytidine induces bacterial colonization and analyzed its mechanism. In addition, we found that the OmpX protein contributes to bacterial colonization.
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| Free Research Field |
細菌学、感染症学
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| Academic Significance and Societal Importance of the Research Achievements |
尿路病原性大腸菌による感染症を治療するために、様々な抗菌薬が使用されているが、近年多くの既存の抗菌薬に対する耐性菌（薬剤耐性菌）が増加しており、本感染症に対する予防法や治療法の開発が期待されている。本研究成果は、尿路病原性大腸菌が病気を引き起こすメカニズムについてのさらなる理解に加えて、本菌による尿路感染症に対する治療法および、予防法の発展に貢献するものである。
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