2021 Fiscal Year Final Research Report
Evaluation and targeting of the autonomous niche of glioma stem cells
| Project/Area Number |
19K07671
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 50010:Tumor biology-related
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | がん幹細胞 / 悪性脳腫瘍 / ニッチ |
|---|
| Outline of Final Research Achievements |
Glioblastomas are fatal because they recur within months after treatment, with limited options for additional therapy. Glioma stem cells (GSCs), the cells causing recurrence form their own niche by secreting components favorable for survival and proliferation. However, the characteristics of the GSC autonomous niche have not been fully elucidated. In this study, we recorded the formation process of the autonomous niche and showed that, consistent with the recurrence patterns of glioblastomas, the niche is formed not only around the tumor mass but also in distant areas within the normal brain. Furthermore, through screening of small molecule inhibitors, we identified several drugs that disrupt the autonomic niche.Importantly, systemic factors were found to significantly influence the response of the tumor to these inhibitors. Further investigations of the interaction of the autonomous niche with systemic factors will thus be necessary to establish anti-niche therapies.
|
| Free Research Field |
腫瘍生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
難治性腫瘍である膠芽腫において、その再発を防ぐ新しい治療戦略の確立が急務である。グリオーマ幹細胞が自ら形成するニッチの成立機構の解明、制御因子及び候補阻害剤の同定は膠芽腫再発機構に関する生物学的理解に貢献し、ニッチを破壊することで膠芽腫の根治につながると期待できる。
|
