Hyperthermia generated by newly developed magnetic nanoparticles for effective treatment of peritoneal dissemination of a stomach cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Okayama University
• Principal Investigator: Kishimoto Hiroyuki 岡山大学, 医学部, 客員研究員 (50613155)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 温熱療法 / 磁性ナノ粒子 / 腹膜播種 / 胃癌

Outline of Final Research Achievements

In the present study, we treated peritoneal metastasis of gastric cancer with magnetic hyperthermia (MHT) using superparamagnetic iron oxide nanoparticle (SPION) as an magnetic nanoparticle (MNP), in an orthotopic mouse model mimicking early peritoneal disseminated disease of gastric cancer. SPIONs of an optimal size were intraperitoneally administered, and an AMF (390 kHz, 28 kAm－1) was applied for 10 minutes, four times every three days. After the MHT treatment, the peritoneal metastases were significantly inhibited compared with the untreated control group. The results of the present study show that MHT can be applied as a new treatment option for disseminated peritoneal gastric cancer.

Free Research Field

磁気温熱療法

Academic Significance and Societal Importance of the Research Achievements

胃癌は、肉眼的に病巣を完全切除できても、腹腔内遊離癌細胞を認めた場合は、術後5年で9割が腹膜播種再発で死亡する。播種病変は標準治療である化学療法では治療困難であるため新たな治療が求められている。我々は、これまで播種病変に治療応用されたことがない交流磁場焼灼療法に注目した。本研究では、発熱能力の高い磁性ナノ粒子を腹腔内投与し、磁場印加して磁性粒子を発熱させて腹膜播種再発の原因となる遊離癌細胞を選択的に死滅させる治療コンセプトを証明し、新しい胃癌治療の可能性を示した。