2021 Fiscal Year Final Research Report
Elucidation of the mechanism of abnormal eating behavior and the development of new treatment methods: An approach involving bone marrow-derived cells
| Project/Area Number |
19K07917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安宅 弘司 鹿児島大学, 医歯学総合研究科, 特任講師 (30563358)
加藤 郁夫 神戸薬科大学, 薬学部, 教授 (70509843)
網谷 東方 鹿児島大学, 医歯学域鹿児島大学病院, 講師 (70535674)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 食欲 / 食行動 / 神経性やせ症 / 肥満症 / 骨髄 / 視床下部 |
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| Outline of Final Research Achievements |
Arginine vasopressin expression was increased in the hypothalamus of mice in the activity-based anorexia model group and the group that was allowed to move spontaneously with a rotation wheel . Moreover, bone marrow-derived cells were found to be accumulated in the paraventricular nucleus of the hypothalamus of mice in the activity-based anorexia model group. Administration of an anti-agouti-related protein antibody or a neuropeptide Y1 receptor antagonist in the activity-based anorexia model group decreased food intake and spontaneous locomotion of mice in the spinning wheel. Notably, mice with mother-infant separation had less open-arm selection in the elevated plus-maze test and longer immobility time in the forced swim test. Furthermore, the food intake and weight was lesser in high-fat-diet-fed mice transplanted with bone marrow cells of high-fat-diet-fed mice than in high-fat-diet-fed mice transplanted with bone marrow cells of normal diet-fed mice.
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| Free Research Field |
心身内科学
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| Academic Significance and Societal Importance of the Research Achievements |
神経性やせ症や肥満症など、食欲・食行動異常を伴う疾患は、先進国を中心に、年々増加し、重要な社会問題となっているが、有効な治療法・予防法の開発は遅れ、学術的に極めて重要な研究課題になっている。本研究による知見から、神経性やせ症の病態に、視床下部の神経ペプチドや母子関係が関与している可能性、肥満症の病態に骨髄細胞が関与している可能性が示唆される。今後、視床下部、生育歴、食習慣、骨髄が、食欲・体重異常症を呈する多くの疾患の治療・予防のための重要なターゲットになることが考えられた。
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