2021 Fiscal Year Final Research Report

Development of posterior scattering photometry detecting ESP measuring device on laboratory medicine

Research Project

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Project/Area Number	19K07936
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Shiga University of Medical Science
Principal Investigator	Endo Yoshihiro 滋賀医科大学, 医学部, 教授 (40263040)
Co-Investigator(Kenkyū-buntansha)	中島滋美滋賀医科大学, 地域医療教育研究拠点, 准教授 (00650764) 清水智治滋賀医科大学, 医学部, 教授 (70402708) 小幡徹滋賀医科大学, 医学部, 客員准教授 (80119776) 田畑貴久滋賀医科大学, 医学部, 非常勤講師 (90278200) 梅田朋子滋賀医科大学, 地域医療教育研究拠点, 准教授 (10402736) 内藤弘之滋賀医科大学, 地域医療教育研究拠点, 准教授 (30311723)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	エンドトキシン / 敗血症 / 敗血症性ショック / エンドトキシンショック
Outline of Final Research Achievements	Endotoxin Scattering Photometry (ESP) method is able to detect endotoxin even in healthy human with non-septic condition since its detection ability is more sensitive than ordinal methods. In this study, we examined the detection range in healthy human receiving medical check‐up and explored the relation between endotoxin and certain diseases. 157 healthy individuals was included in this study. The detection range was 0.025-166.4pg/mL. 90% of cases were under 13pg/mL that is suspected as diagnostic cut-off levels of sepsis by ESP methods. There was no relation between endotoxin and hyperlipidemia, smoking, Alcohol intake, degree of obesity, BMI, high sensitivity CRP, past medical history. We could not find any relation in endotoxin and clinical factors in this study. Accumulation of cases decreased because of the influence of COVID-19 infection, therefore, we would like to evaluate the relations in the limited diseases in the future study.
Free Research Field	クリティカルケア
Academic Significance and Societal Importance of the Research Achievements	従来法では、検出されないエンドトキシンが、全対象者で「値」として検出できることがわかった。エンドトキシンが関連するとされている生活習慣病や慢性維持透析などの慢性疾患での関連を検討できる可能性があることが把握できた。さらに多くの『健常』と思われているヒトのエンドトキシンについて検討する事により、現状では、未解明であるEtの意義について解明の糸口になる可能性や重症化や合併症の予防につながる可能性がある。