2022 Fiscal Year Final Research Report

Circulating microRNAs associated with smoking-induced vascular endothelial dysfunction

Research Project

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Project/Area Number	19K07943
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Osaka Metropolitan University (2022) Osaka City University (2019-2021)
Principal Investigator	Yasuhiko Takeoto 大阪公立大学, 大学院医学研究科, 客員教授 (20364002)
Co-Investigator(Kenkyū-buntansha)	冨田修平大阪公立大学, 大学院医学研究科, 教授 (00263898) 首藤太一大阪公立大学, 大学院医学研究科, 教授 (20295687) 葭山稔大阪公立大学, 大学院医学研究科, 名誉教授 (30240956) 山口雄大大阪公立大学, 大学院医学研究科, 医員 (40726080) 福本一夫大阪公立大学, 大学院医学研究科, 講師 (20897392)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	smoking / endothelial dysfunction / circulating microRNA
Outline of Final Research Achievements	We analyzed the differential expression of total of 20 circulating microRNAs between smokers who had impaired flow-dependent dilation (FMD) responses and nonsmokers who did not. We found the significant differences in the expression of circulating miR-92a-3p and miR-126-5p. After achieving smoking cessation, the expression of circulating miR-92a-3p significantly increased and miR-126-3p and miR-126-5p tended to increase. In addition, the change in FMD after smoking cessation was suggested to be correlated with the pression of circulating miR-1, miR-126-3p, and miR-126-5p before smoking cessation treatment.
Free Research Field	Internal medicine
Academic Significance and Societal Importance of the Research Achievements	喫煙による早期血管障害や、禁煙達成による早期血管障害との関連が示唆される血中のmiRが明らかとなった。これら血中のmiRが、喫煙による早期血管障害のバイオマーカーとなりうる可能性があり、喫煙者における早期血管障害の機序へのmiRの関わりの解明につながる可能性が示唆された。