The role of tau protein and 5-HT1B receptor in the amyloid associated depression by positron emission tomography

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Nippon Medical School
• Principal Investigator: Tateno Amane 日本医科大学, 大学院医学研究科, 大学院教授 (50297917)
• Co-Investigator(Kenkyū-buntansha): 大久保 善朗 日本医科大学, 大学院医学研究科, 大学院教授 (20213663) ; 荒川 亮介 日本医科大学, 医学部, 准教授 (40350095)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: アミロイド関連うつ病 / タウ蛋白 / セロトニン1B受容体 / ポジトロンエミッショントモグラフィー

Outline of Final Research Achievements

The number of patients who completed the PET examinations was less than half of the originally planned number (15) due to a one-year interruption in both subject recruitment and PET examinations caused by the spread of coronary infection. Tau PET imaging was performed in 8 subjects (6 females and 2 males, mean age 74.1 years), and 5-HT1B receptor PET was also performed in 4 subjects (3 females and 1 male, mean age 69.5 years). Analysis revealed significant tau protein accumulation in the hippocampal region in one patient, and 5-HT1B receptor accumulation in the hippocampal region.
It was not possible to determine from the present study whether 5-HT1B receptors and tau protein accumulation are related in terms of distribution, density, and degree in the group of patients with amyloid-related depression.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

今回有意なタウ蛋白集積を認めた例が少なかったことは、被験者が初発年齢70歳以降2名、70歳未満6名と老年期初発症例が少なかったことが影響していると考えている。我々はこれまでのPET研究でアミロイド関連うつ病において70歳未満（14.3%）と70歳以降（65.4%）とうつ病初発年齢によってAβ陽性率に差があることを報告している。このため今後は70歳以降の高齢発症例を対象とした研究が必要と考える。