2022 Fiscal Year Final Research Report

Development of less toxic radiotherapy using IMPT for head and neck cancer

Research Project

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Project/Area Number	19K08088
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Hokkaido University
Principal Investigator	Yasuda Koichi 北海道大学, 大学病院, 助教 (00431362)
Co-Investigator(Kenkyū-buntansha)	加納里志北海道大学, 大学病院, 講師 (00374421) 水町貴諭北海道大学, 医学研究院, 客員研究員 (00507577) 高尾聖心北海道大学, 大学病院, 助教 (10614216) 田村昌也北海道大学, 大学病院, 助教 (40504775)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	IMPT / 陽子線治療 / 頭頸部癌
Outline of Final Research Achievements	DVH analysis, development of the NTCP model and establishment of indicators for radiation therapy planning to reduce adverse effects such as dermatitis, dry mouth, dysgeusia, mucositis and dysphagia were performed. A methodology was established to objectively demonstrate a lower probability of adverse effects. Comparisons using the NTCP models and attempts to assess the quality of the radiation therapy plan while predicting the probability of adverse effects were initiated in clinical practice. A quality-of-life survey was conducted to objectively identify the 'pain' felt by patients. A comparison of actual adverse effects between IMPT and IMRT showed that dysgeusia was lower with IMPT, but did not show a statistically significant difference. Dysphagia due to mucositis was significantly lower with IMPT. At 6 months after radiation therapy, dysgeusia, dysphagia and dry mouth were significantly lower with IMPT. These results suggest the potential benefits of spot-scanning IMPT.
Free Research Field	放射線治療
Academic Significance and Societal Importance of the Research Achievements	頭頸部癌に対する放射線治療は、近年IMRTなどの技術開発があるものの、未だに辛い副作用を患者さんに強いている。本研究は最先端放射線治療の一つであるスポットスキャニングIMPTの技術を用いてその副作用を低減させる試みである。いくつかの副作用やその回復においてスポットスキャニングIMPTの利点が示され、その有用性が示唆される結果である。最先端放射線治療の技術開発という点で学術的な価値を持つとともに、患者のQOLをできるだけ維持した癌治療法開発という点で、社会に広く利益をもたらしうる研究と考えられる。