2021 Fiscal Year Final Research Report
Development of new electrodes for radiofrequency ablation.
| Project/Area Number |
19K08108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
児玉 大志 兵庫医科大学, 医学部, 助教 (20422834)
高木 治行 兵庫医科大学, 医学部, 准教授 (30378377)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ラジオ波凝固治療 / RFA / 肝臓 / IVR |
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| Outline of Final Research Achievements |
In this research, we evaluated the coagulative performance of a novel 21-gauge (G) internally cooled radiofrequency (RF) electrode using ex vivo and in vivo rat liver.Anti-tumor effect was also evaluated by mouse subcutaneous tumor model.
Results from ex vivo experiments showed the ablation volume increased significantly when RF energy was applied with the chilled water circulation. The largest ablation zone was created with applied RF power of 5 W. From in vivo experiments, results show that the ablation volume reached its maximum value when RF power of 7 W was applied. Histopathological examination showed a delineated coagulation necrosis at 24 h after RF ablation. The ablation zone border became clearer and fibrotic change was also observed at 7 days after RF ablation. Anti-tumor effect was excellent, if tumor size was less than 1cm.
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| Free Research Field |
Interventional Radiology (IVR)
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| Academic Significance and Societal Importance of the Research Achievements |
ラジオ波凝固治療は近い将来、本邦でも肝以外の臓器へと治療適応が拡大される見込みである。そこで本研究では、今後のRFA治療適応拡大と小型臓器や小児がん等への応用を見据えて、新しく開発した細径RF電極針の凝固性能および抗腫瘍効果を行った。本研究の結果、細径RF電極針の至適使用条件や抗腫瘍効果が明らかとなり、今後の臨床応用へと展開させていく上で有用な情報が得られた。
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