Quantitative analysis of the contribution of tumor vascular injury to the anti-tumor effect of X-rays using boron neutron capture reaction

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K08134
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: ONO KOJI 大阪医科薬科大学, BNCT共同臨床研究所, 所長 (90122407)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: BNCT / 腫瘍細胞選択的殺細胞効果 / 硼素化合物 / BPA / BSH / 悪性脳腫瘍

Outline of Final Research Achievements

Boron neutron capture therapy (BNCT) is expected to have s selective cytocidal effect on tumor cells, but in addition to its antitumor effect, damage to the vascular system that supports the growth of tumors should also contribute significantly. X-ray therapy is not selective to tumor cells, so it is considered that vascular damage also contributes significantly. In this study, the data from basic and clinical research on BNCT was reanalyzed, and it was found that the number of cells required to cure a tumor can be accurately estimated by the direct cytocidal effect. In addition, an analysis of the results of BNCT for glioblastoma revealed that the results can be reasonably explained by the direct cytocidal effect.

Free Research Field

医学（放射線科学）

Academic Significance and Societal Importance of the Research Achievements

BNCTの特性である抗腫瘍効果の腫瘍細胞選択的特徴が明らかになった。