Development of accelerator produced radionuclides for radioisotope therapy application

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka University
• Principal Investigator: Ooe Kazuhiro 大阪大学, 医学部附属病院, 特任助教(常勤) (90610303)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 核医学治療 / 加速器製造核種 / ベータ線放出核種

Outline of Final Research Achievements

In this study, we aimed to develop accelerator produced radionuclides, which can be supplied domestically, for radioisotope therapy. As candidate radionuclides, silver-111 and cerium-141 were selected, and accelerator production and purification methods for these radionuclides were investigated. As for Ag-111, excitation functions in the nuclear reaction between palladium and deuterium beam were obtained, and the separation of Ag-111 from palladium by anion exchange method was successfully carried out. As for cerium-141, barium oxide was selected as an appropriate target material. The production of cerium-141 in the nuclear reaction between barium oxide and helium-4 beam was conducted, and separation of Ce-141 from barium oxide by extraction chromatography was achieved.

Free Research Field

放射化学

Academic Significance and Societal Importance of the Research Achievements

核医学治療用の放射性核種は、現在すべて輸入に頼っており、その供給が海外情勢に大きな影響を受ける。そのため、治療用の放射性核種を国内製造・供給することに大きな期待が寄せられている。本研究では銀-111およびセリウム-141について、加速器による製造法と、ターゲット物質からの分離精製法の開発を達成し、治療用核種の加速器を用いた国内製造・供給に向けて大きな一歩となると考えられる。