2021 Fiscal Year Final Research Report

Harmonization of FDG-PET/CT and an imaging biomaker: A Japanese multicenter study

Research Project

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Project/Area Number	19K08187
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Hyogo Medical University
Principal Investigator	Kitajima Kazuhiro 兵庫医科大学, 医学部, 准教授 (80448860)
Co-Investigator(Kenkyū-buntansha)	山門亨一郎兵庫医科大学, 医学部, 教授 (20263022) 甲斐田勇人近畿大学, 医学部, 講師 (40299425) 伊藤公輝国立研究開発法人国立がん研究センター, 中央病院, 医長 (40602074) 関根鉄朗日本医科大学, 医学部, 講師 (00747826) 大崎洋充群馬県立県民健康科学大学, 診療放射線学部, 准教授 (90392349) 濱田顕近畿大学, 大学病院, 助教 (80772954)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	悪性腫瘍 / FDG-PET/CT / ハーモナイゼーション
Outline of Final Research Achievements	Using the plural FDG-PET/CT devices of 4 facilities (Hyogo College of Medicine, Kinki University, National Cancer Center center Hospital, Nippon Medical School), I was able to confirm that SUVmax which a phantom experiment provided fitted into the count recovery curve that Japan nuclear medicine recommended in the thing using the most suitable Gaussian filter well. Then, I gathered Dicom images of FDG-PET/CT before treatment of the clinical example (breast cancer, lung cancer, tongue cancer) of 4 facilities and proved the thing that was useful as the imaging biomarker which a half fixed-quantity level after the harmonization (TLG which is SUVmax of the biggest accumulation, MTV, SUVmean which are the volume of the accumulation and the product of MTV) reflected the malignancy of cancer, and enabled a convalescence (a recurrence and the death) prediction.
Free Research Field	腫瘍PET
Academic Significance and Societal Importance of the Research Achievements	FDG-PET/CT検査で得られる、癌へのFDG集積の程度や広がり（体積）を表す指標としてSUVmax、MTV、TLGなどがありますが、異なるPET/CT装置では少し違った値をとる為に同じ土俵で扱う事が今まではできませんでしたが、今回の研究でうまくハーモナイゼーション（標準化）する方法を開発しました。そしてその方法を実際の臨床症例（4施設の肺癌症例と乳癌症例と舌癌症例）に用いた検討でもハーモナイゼーション後の各種指標は予後と良好に相関する優れたイメージングバイオマーカーになり得ることを明らかにできました。