2021 Fiscal Year Final Research Report
The radioprotective and antitumor activities of hot-water extracts from the basidiomycete (Agaricus Blazei Murill) on X ray irradiation mice.
Project/Area Number |
19K08196
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Chiba University |
Principal Investigator |
UNO Takashi 千葉大学, 大学院医学研究院, 教授 (30302540)
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Co-Investigator(Kenkyū-buntansha) |
根本 未歩 (渡辺未歩) 千葉大学, 大学院医学研究院, 講師 (50568665)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 放射線被ばく / 担子菌抽出物 / 腫瘍増殖抑制 / 放射線治療 |
Outline of Final Research Achievements |
We performed basal examination of ABM (Freezing dryness polysaccharides, Agaricus Blazei Murill) about the protection effect of whole body X-ray irradiation in normal mice. In addition, combination effects with X-ray irradiation and ABM administration were investigated in Meth A tumor-bearing mice. The ABM groups in which performed immediately after irradiation ABM treatment group showed in protection from whole body exposure (8.0Gy). The oral administrated groups of ABM and X-ray irradiation moderately inhibited the growth of Meth A tumor cells implanted (s. c.) in mice. Development of implanted tumor was strongly inhibited by the combination of ABM treatment after irradiation. These results suggest that the radiation exposure protection effect of AMB inhibits bone marrow death, not action as radical scavenger.
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Free Research Field |
放射線科学、放射線治療学
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Academic Significance and Societal Importance of the Research Achievements |
被ばく事故等の放射線障害や放射線治療に伴う副作用の軽減を目的として放射線防護効果が認められる物質が研究されている。本研究では、アガリクス(菌糸体・子実体)抽出物/ABMの放射線防護効果および照射とABMの併用による抗腫瘍効果について基礎的検討を実施した。マウスに対する致死線量全身照射からの防護効果および移植腫瘍に対するABMと放射線照射の併用では、明らかな効果が認められた。また、これらの効果は照射(被ばく)後のABM投与がより顕著であり、安全で有効な防護剤となる可能性が示唆された。
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