Development of emulsification device in TACE for HCC

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K08205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nara Medical University
• Principal Investigator: Masada Tetsuya 奈良県立医科大学, 医学部, 研究員 (60727593)
• Co-Investigator(Kenkyū-buntansha): 田中 利洋 奈良県立医科大学, 医学部, 教授 (70326338)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: インターベンショナル・ラジオロジー / 肝細胞癌 / 肝動脈化学塞栓療法 / TACE

Outline of Final Research Achievements

Transarterial chemoembolization is widely used as a standard treatment for hepatocellular carcinoma. The technique most frequently used is that an emulsion is created by mixing anticancer drug solution and lipiodol and it is selectively injected via tumor feeding artery. Recently, an emulsification device with multi-pour glass membrane was developed and stability, high accumulation effect and high embolic effect were achieved. In this study, we evaluated this device in ex vivo and clinical examinations. As the results, slow release of anticancer drugs and dens lipiodol accumulation were shown.

Free Research Field

インターベンショナル・ラジオロジー

Academic Significance and Societal Importance of the Research Achievements

本研究で開発、評価された新規デバイスを用いて肝動脈化学塞栓療法をおこなうことで、肝細胞癌患者に対するTACEの治療成績向上が得られ、患者の予後延長が期待できる。