Redox imaging of Breast Cancer Animal Model by DNP-MRI

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Gifu University
• Principal Investigator: Nozawa Asae 岐阜大学, 大学院医学系研究科, 特任助教 (90802786)
• Co-Investigator(Kenkyū-buntansha): 兵藤 文紀 岐阜大学, 大学院医学系研究科, 特任准教授 (10380693) ; 松尾 政之 岐阜大学, 大学院医学系研究科, 教授 (40377669) ; 田中 秀和 山口大学, 大学院医学系研究科, 教授 (30509782)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: レドックス / 乳癌 / DNP

Outline of Final Research Achievements

It is known that abnormal redox status of tumors is a cause of resistance in anticancer drugs and radiotherapy. In this study, we conducted basic research on redox imaging of tumors by redox probe/ in vivo DNP-MRI using a mouse model of breast cancer tumors. In some breast cancer cells, poor probe distribution were observed due to intratumoral necrosis and low vascularity. On the other hand, in a mouse model of spontaneous breast cancer, the DNP probe was rapidly distributed throughout the tumor and provided clear redox images. This technique is expected to be applied to early diagnosis of tumors in the future.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

本研究により、乳がんにおける創薬では、薬効評価までの時間短縮に伴う創薬過程の加速化とランニングコストの軽減、実臨床においては、早期の治療効果の予測による患者のQOLの向上が見込まれる