2022 Fiscal Year Final Research Report
Functional elucidation of an organic anion transporter which is overexpressed in undernutrition condition during fetus development.
| Project/Area Number |
19K08274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宇田川 潤 滋賀医科大学, 医学部, 教授 (10284027)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | DOHaD / サルコペニア |
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| Outline of Final Research Achievements |
We generated SLC22a23 gene knockout rat. The SLC22a23 gene knockout rat showed reduced weight gain after weaning. The total distance travelled was statistically significantly increased in the knockout rat in our open-field analysis. In contrast, forelimb traction was statistically significantly reduced in the knockout rat. The weights of total brain and lower limb muscles were statistically significantly reduced in the knockout rat. These results suggest the SLC22a23 gene knockout rat have a sarcopenia-like phenotype.
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| Free Research Field |
DOHaD
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| Academic Significance and Societal Importance of the Research Achievements |
SLC22a23ノックアウトラットは未だ報告されておらず、本研究での解析が新規であることから、学術的意義がある。本研究でSLC22a23ノックアウトラットが、サルコペニア様の表現型を示すことから、SLC22a23輸送体の基質を同定することで、サルコペニアを防ぐための知見が得られる可能性があり、社会的意義がある。
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