Mechnism of gastric cancer heterogeneity by comprehensive genetic analysis of clinical specimens

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Yokohama City University
• Principal Investigator: SHIBATA Wataru 横浜市立大学, 医学研究科, 客員准教授 (00435819)
• Co-Investigator(Kenkyū-buntansha): 金子 裕明 横浜市立大学, 医学部, 助教 (20760078) ; 前田 愼 横浜市立大学, 医学研究科, 教授 (40415956)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 胃癌 / 未分化癌 / 分化型癌

Outline of Final Research Achievements

Most early-stage gastric cancers are purely differentiated cancers, but advanced cancers contain undifferentiated components, and it is thought that the cancer changes from differentiated cancers to undifferentiated cancers as it progresses. On the other hand, there are cases of early stage cancer with only undifferentiated components. In the clinicopathological examination of undifferentiated mixed early stage cancer, the tumor diameter was slightly larger (16.1 mm vs 24.4 mm) and SM invasive cancer was more common (12.2% vs 45.7%). Staining of E-cadherin as a marker for undifferentiated tissue was deficient in cancer cells in many purely undifferentiated cases, but the expression was decreased in mixed cases, but there were few cases in which it was deficient. rice field. It was suggested that there are different pathways for the development of undifferentiated cancer in gastric cancer.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

胃癌の不均一性は胃癌の進行と関連しており、早期癌においても予後不良の因子と考えられている。本研究では早期胃癌においても、未分化成分の混在がその深部浸潤と関連する可能性を示した。また、未分化成分の出現には、分化型から発生するものと、未分化型として発生する経路があり、進行癌における治療法の選択にも考慮が必要である可能性が示唆された。