2022 Fiscal Year Final Research Report
An advanced ultrasound application used to assess microvessels in cardiovascular diseases: superb microvascular imaging
| Project/Area Number |
19K08483
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
飯野 健二 秋田大学, 医学系研究科, 准教授 (30400485)
佐藤 和奏 秋田大学, 医学系研究科, 助教 (50748283)
飯野 貴子 秋田大学, 医学部, 助教 (70620871)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 微小血管 / 血管エコー / 重症下肢虚血 / 高安動脈炎 / 頸動脈プラーク / 心不全 / 反応性充血 |
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| Outline of Final Research Achievements |
A novel ultrasound modality termed superb microvascular imaging (SMI) has enabled visualization of microvessels. SMI ultrasound studies have significantly extended our knowledge of tissue microcirculation and the arterial microenvironments of atherosclerotic lesions. We here present a current knowledge on the utility of SMI assessment of vascular diseases and highlight certain peripheral microcirculation disorders for which SMI is particularly valuable. The evidence indicates that SMI reveals the foot microcirculation and yields a quantitative vascular index in line with the angiosome concept; vascularization of the carotid arterial wall detected by SMI is a potential marker of disease activity in patients with Takayasu arteritis; and, SMI can detect intraplaque neovascularization and usefully assess carotid plaque vulnerability. In general, microcirculatory evaluation by SMI is an attractive field for future research on therapeutic strategies fo peripheral vascular diseases.
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| Free Research Field |
循環器内科学 超音波医学
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| Academic Significance and Societal Importance of the Research Achievements |
これまで動物を用いた基礎実験や剖検でしか知りえなかった病態下での微小血流の挙動を、本研究ではリアルタイムで定量・評価できることを示した。この成果は未だ不明な心血管難病の病態メカニズム解明や新規検査法・治療法の開発など、今後の循環器領域研究の発展に大きく寄与すると考えられる。とくに高安動脈炎でのSMIによる頸動脈壁内血管増生の検出はFDG/PET検査に代わるより安価で簡便な活動性評価方法となる可能性を示唆した。
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