Role of Regeneration-Associated Cells in Myocardial Ischemia

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Tokai University
• Principal Investigator: Asahara Takayuki 東海大学, 医学部, 客員教授 (20246200)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 再生環境 / 血管再生作用 / 抗炎症作用 / 抗免疫作用

Outline of Final Research Achievements

Phenotypes of blood cells in the regenerative microenvironment play an important role in organ and vascular regeneration mechanisms. In chronic inflammatory diseases such as diabetes, obesity, and aging, phenotypic abnormalities in the regenerative microenvironment are thought to cause regenerative environment failure, leading to the progression of atherosclerosis and ischemic diseases. In this study, we isolated regenerative environmental cells in healthy mice and in tissue ischemia models of diabetes, obesity, and aging, and compared their phenotypes and functions. We were able to clarify the dynamics of regenerative environmental cells after myocardial infarction. However, we still need to clarify the mechanism and therapeutic application of these cells.

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

糖尿病あるいは高齢による虚血組織における慢性炎症と再生不全は、再生環境細胞の機能不全が大きな原因になっていると考えられ、細胞のフェノタイプ解析によって、それを証明することが出来た。このことは、再生環境細胞の機能不全の原因を探ることで疾患あるいは高齢による治癒不全を治療出来る可能性を示している。その治療薬の開発で、疾患あるいは高齢における健康寿命を大幅に延伸できると期待され、国民の健康生活の質を高め医療費の削減に大いに貢献するものと考える。