2021 Fiscal Year Final Research Report
Development of novel diagnostic and therapeutic methods for cardiac diseases based on the elucidation of the regulatory mechanism of glycosylation of proBNP
| Project/Area Number |
19K08580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑原 宏一郎 信州大学, 学術研究院医学系, 教授 (30402887)
錦見 俊雄 京都大学, 医学研究科, 非常勤講師 (80291946)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | proBNP / 糖鎖修飾 |
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| Outline of Final Research Achievements |
BNP is a cardioprotective peptide secreted from the heart. We have reported that the precursor proBNP, which is much less bioactive than BNP, exists in the blood and that glycosylation of proBNP is involved in its secretion mechanism. In this study, we attempted to analyze glycan structures to create a new diagnostic method by elucidating glycan structures. It became clear the possibility that the glycan structures may be diverse in proBNP produced in non-cardiac myocytes, and we will continue to analyze them in more physiological situations from cardiac myocytes. On the other hand, the involvement of molecules other than miR30 and GALNT in glycosylation and the possibility that the molecules involved may change depending on the pathological condition were found, and we will continue further research in order to create new treatment methods.
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| Free Research Field |
分子心臓病学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、低活性のproBNP分泌メカニズムの一端が明らかとなり、これらの分子メカニズムを修飾することで、心不全の新たな診断法や、活性の強いBNPの分泌が促進されるような新たな心不全治療の開発につながる可能性が有る意義のある研究成果が得られたと考える。
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