薬剤性及び放射線肺障害の新規バイオマーカー探索による肺がん個別化治療の確立

2019 Fiscal Year Research-status Report

• Project/Area Number: 19K08606
• Research Institution: Fukushima Medical University
• Principal Investigator: 谷野 功典 福島県立医科大学, 医学部, 准教授 (10443863)
• Co-Investigator(Kenkyū-buntansha): 海老名 雅仁 東北医科薬科大学, 医学部, 教授 (10280885) ; 二階堂 雄文 福島県立医科大学, 医学部, 助教 (20583347) ; 柴田 陽光 福島県立医科大学, 医学部, 教授 (60333978)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 肺がん / 薬剤性肺障害 / 放射線肺障害 / 予測因子 / プレシージョン・メディシン / 細胞外マトリックス / miRNA / 遺伝素因

Outline of Annual Research Achievements

本研究では、肺がん患者の治療における放射線肺障害、薬剤性肺障害の発症をあらかじめ予測することによるプレシージョン・メディシンの確立を目的としている。
そのために、血中細胞外マトリックス濃度、miRNAや遺伝的背景を肺障害発症患者を非発症患者と比較すること、または発症前後の経過を比較する。
現在、障害発症前の肺がん患者についての血液検体の収集を行っており、検体は徐々に集まってきている状況である。また、血中細胞外マトリックス濃度の測定については検体が集まり次第、測定を開始することが、以前の検討でも東洋の検討を行っており、すでに測定を行うことができる体制は確立している。
一方、miRNAの検討と遺伝的背景についての検討については、まだ確立しておらず、遅れがでている。更に、放射線肺障害や薬剤性肺障害発症肺がん患者の解析には発症を迅速に把握して検体収集する必要があることもあり、検体収集に遅れがでている。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

放射線肺障害、薬剤性肺障害発症前の肺がん患者の検体収集は進んでいるが、発症後の検体採取に遅れがあるため。

Strategy for Future Research Activity

放射線肺障害や薬剤性肺障害を発症した患者を確実に把握して、検体収集に努める。

Causes of Carryover

物品、測定用試薬の購入がまだ少なかったことと、学会参加に伴う旅費などが多かったため。今後は、対象患者の選定と急ぎ、解析を急ぐ。

Research Products

• [Journal Article] Multidisciplinary team approach on a case of bilateral interstitial pneumonia (2020)
  • Author(s): Yijun He, Yu Xia, Yongbin Hu, Hui Zhou, Hongjun Zhao, Qun Luo, Wanli Ma, Martin Kolb, Amornpun Wongkarnjana, Reoto Takei, Yoshinori Tanino, Jie Meng
  • Journal Title: J Xiangya Med Volume: 5 Pages: 1
  • DOI: 10.21037/jxym.2019.12.01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical characteristics of cancer-associated myositis complicated by interstitial lung disease: a large-scale multicentre cohort study (2020)
  • Author(s): Yuko Kaneko, Takahiro Nunokawa, Yoshinori Taniguchi, Yukie Yamaguchi, Takahisa Gono, Kenichi Masui, Atsushi Kawakami, Yasushi Kawaguchi, Shinji Sato, Masataka Kuwana, JAMI investigators
  • Journal Title: Rheumatology Volume: 59 Pages: 112-19
  • DOI: 10.21037/jxym.2019.12.01
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two cases with autoantibodies to small ubiquitin-like modifier activating enzyme: a potential unique subset of dermatomyositis-associated interstitial lung disease (2019)
  • Author(s): Takahisa Gono, Yoshinori Tanino, Ayumi Nishikawa, Takaya Kawamata, Kenichiro Hirai, Yuka Okazaki, Yoko Shibata, Masataka Kuwana
  • Journal Title: Int J Rheum Dis Volume: 22 Pages: 1582-86
  • DOI: 10.1111/1756-185X.13593
  • Peer Reviewed
• [Journal Article] A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); an autopsy case report (2019)
  • Author(s): 14.Suzuki Y, Minemura H, Tomita H, Saito M, Watanabe N, Umeda T, Kawamata T, Rikimaru M, Morimoto J, Koizumi T, Togawa R, Sato Y, Hirai K, Uematsu M, Nikaido T, Fukuhara N, Fukuhara A, Sato S, Saito J, Kanazawa K, Tanino Y, Shibata Y
  • Journal Title: Lung cancer Volume: 136 Pages: 105-108
  • DOI: 10.1016/j.lungcan.2019.08.018
  • Peer Reviewed
• [Journal Article] Syndecan-4 inhibits the development of pulmonary fibrosis by attenuating TGF-β signaling (2019)
  • Author(s): Yoshinori Tanino, Xintao Wang, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Masami Kikuchi, Charles Frevert, Mishie Tanino, Tetsuhito Kojima, Yoko Shibata
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 4989
  • DOI: 10.3390/ijms20204989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large expert-curated database for benchmarking document similarity in biomedical literature search (2019)
  • Author(s): Peter Brown, RELISH Consortium and Yaoqi Zhou
  • Journal Title: Database (Oxford) Volume: 2019 Pages: 1-66
  • DOI: 10.1093/database/baz085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Baseline Serum Lactate Dehydrogenase and %VC may Predict the Short Time Decline of FVC in Patients with Idiopathic Pulmonary Fibrosis (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Mikako Saito, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Kenya Kanazawa, and Yoko Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Are The Autoantibodies Associated with The Distinctive Clinical Characteristics in Interstitial Pneumonia Patients with Systemic Sclerosis? (2019)
  • Author(s): R Togawa, Y Tanino, T Nikaido, Y Sato, T kawamata, M Saito, N Watanabe, T Umeda, M Rikimaru, Y Suzuki, M Uematsu, H Minemura, A Fukuhara, S Sato, J Saito, K Kanazawa, Y Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Clinical Significance of Desaturation during a 6-minute Walk Test in Patients with Idiopathic Interstitial Pneumonia without Hypoxemia at Rest (2019)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Mikako Saito, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Kenya Kanazawa, and Yoko Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Prognostic analysis of idiopathic interstitial pneumonias with rheumatologic features: A prospective multicenter cohort study (PAIR cohort study) (2019)
  • Author(s): Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takafumi Suda
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] PAR-2 antagonist inhibits BLM-induced lung fibrosis (2019)
  • Author(s): T. Suzuki, X. Wang, T. Nikaido, Y. Tanino, M. Saitou, M. Munakata, Y. Shibata, K. Niitsuma
  • Organizer: European Respiratory Society International Meeting
  • Int'l Joint Research
• [Presentation] Clinical Characteristics of Idiopathic Interstitial Pneumonia with Anti-ARS Antibody (2019)
  • Author(s): Takaya Kawamata, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Hikaru Tomita, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Jumpei Saito, Kenya Kanazawa,Yoko Shibata
  • Organizer: WASOG/JSSOG 2019
  • Int'l Joint Research
• [Presentation] Syndecan-4 inhibits the development of pulmonary fibrosis by attenuating TGF-β signaling (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Xintao Wang, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Masami Kikuchi, Charles W. Frevert, Mishie Tanino, Tetsuhito Kojima , Yoko Shibata
  • Organizer: 11th International Conference on Proteoglycan
  • Int'l Joint Research
• [Presentation] Predictive factors for mortality in anti-melanoma-associated gene 5 antibody-associated interstitial lung disease (2019)
  • Author(s): Takahisa Gono, Kenichi Masui, Naoshi Nishina, Shinji Sato, Masataka Kuwana and JAMI investigators
  • Organizer: ACR/ARP annual meeting
  • Int'l Joint Research
• [Book] Advances in Medicine and Biology (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Xintao Wang, Yoko Shibata
  • Total Pages: 171-193
  • Publisher: Nova Science Publishers, Inc, NY
  • ISBN: 978-1-53615-065-0
• [Book] 呼吸器疾患最新の治療2019-2020 (2019)
  • Author(s): 谷野功典
  • Total Pages: 198-201
  • Publisher: 南江堂
  • ISBN: 978-4-524-24557-4
• [Book] 今日の処方 改訂第6版 (2019)
  • Author(s): 谷野功典
  • Total Pages: 198-199
  • Publisher: 南江堂
  • ISBN: 978-4-524-25119-3