薬剤性及び放射線肺障害の新規バイオマーカー探索による肺がん個別化治療の確立

2022 Fiscal Year Research-status Report

• Project/Area Number: 19K08606
• Research Institution: Fukushima Medical University
• Principal Investigator: 谷野 功典 福島県立医科大学, 医学部, 准教授 (10443863)
• Co-Investigator(Kenkyū-buntansha): 海老名 雅仁 東北医科薬科大学, 医学部, 教授 (10280885) ; 二階堂 雄文 福島県立医科大学, 医学部, 助教 (20583347) ; 柴田 陽光 福島県立医科大学, 医学部, 教授 (60333978)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 肺がん / 薬剤性肺障害 / 放射線肺障害 / 予測因子 / プレシージョン・メディシン / 細胞外マトリックス / miRNA / 遺伝素因

Outline of Annual Research Achievements

本研究では、肺がん患者の治療における放射線肺障害、薬剤性肺障害の発症をあらかじめ予測することによるプレシージョン・メディシンの確立を目的としている。
そのために、血中細胞外マトリックス濃度、miRNAや遺伝的背景を肺障害発症患者を非発症患者と比較すること、または発症前後の経過を比較する。
現在、肺障害発症前後の肺がん患者についての血液検体の収集を行っており、検体は徐々に集まってきている状況である。また、血中細胞外マトリックス濃度の測定については一部測定を行ったが、更に検体が集まり次第、測定を開始することが、以前の検討でも同様の検討を行っており、すでに測定を行うことができる体制は確立しているが、COVID-19パンデミックの影響もあり、検体収集と測定が遅れているため、検体収取と測定解析を急ぐ必要がある。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

放射線肺障害、薬剤性肺障害発症前の肺がん患者の検体収集は進んでいるが、COVID-19の影響もあり、発症後の検体採取に遅れがあるため。

Strategy for Future Research Activity

放射線肺障害や薬剤性肺障害を発症した患者を確実に把握して、検体収集に努めるとともに測定を並行して進める。

Causes of Carryover

COVID-19の影響で検体収集が遅れ、その分試薬購入が少なかった。一方、年度終盤にはCOVID-19が落ち着いてきたこともあり、海外を含めた学会参加での情報収集を行ったため、旅費が多くなった。今後は、検体の解析を急いで進めるために試薬購入などの使用を増やす計画である。

Research Products

• [Journal Article] Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias (2022)
  • Author(s): Enomoto Noriyuki、Homma Sakae、Inase Naohiko、Kondoh Yasuhiro、Saraya Takeshi、Takizawa Hajime、Inoue Yoshikazu、Ishii Hiroshi、Taguchi Yoshio、Izumi Shinyu、Yamano Yasuhiko、Tanino Yoshinori、et al.
  • Journal Title: Thorax Volume: 77 Pages: 143～153
  • DOI: 10.1136/thoraxjnl-2020-216263
  • Peer Reviewed
• [Journal Article] Development of dermatomyositis after anti-transcriptional intermediary factor 1-γ antibody seroconversion during treatment for small cell lung cancer (2022)
  • Author(s): Sato Yuki、Tanino Yoshinori、Nikaido Takefumi、Togawa Ryuichi、Kawamata Takaya、Watanabe Natsumi、Sato Riko、Yamada Ryuki、Onuma Takumi、Tomita Hikaru、Saito Mikako、Rikimaru Mami、Morimoto Julia、Suzuki Yasuhito、Minemura Hiroyuki、Saito Junpei、Kanazawa Kenya、Yamada Syoki、Hashimoto Yuko、Shibata Yoko
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Pages: 199
  • DOI: 10.1186/s12890-022-01974-4
  • Peer Reviewed / Open Access
• [Journal Article] Mortality Risk Stratification Using Cluster Analysis in Patients With Myositis-Associated Interstitial Lung Disease Receiving Initial Triple-Combination Therapy (2022)
  • Author(s): Gono Takahisa、Masui Kenichi、Sato Shinji、Kuwana Masataka、et al.
  • Journal Title: Frontiers in Medicine Volume: 9 Pages: 883699
  • DOI: 10.3389/fmed.2022.883699
  • Peer Reviewed / Open Access
• [Journal Article] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force (2022)
  • Author(s): Wang Qingbo S.、et al.
  • Journal Title: Nature Communications Volume: 13 Pages: 4830
  • DOI: 10.1038/s41467-022-32276-2
  • Peer Reviewed / Open Access
• [Journal Article] Bioinformatic identification and analysis of immune-related chromatin regulatory genes as potential biomarkers in idiopathic pulmonary fibrosis (2022)
  • Author(s): Li Kaixin、Liu Pulin、Zhang Wei、Liu Xue、Tanino Yoshinori、Koga Yasuhiko、Yan Xiaoyan
  • Journal Title: Annals of Translational Medicine Volume: 10 Pages: 896～896
  • DOI: 10.21037/atm-22-3700
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DOCK2 is involved in the host genetics and biology of severe COVID-19 (2022)
  • Author(s): Namkoong Ho、et al.
  • Journal Title: Nature Volume: 609 Pages: 754～760
  • DOI: 10.1038/s41586-022-05163-5
  • Peer Reviewed / Open Access
• [Journal Article] Clinical effect of early administration of tocilizumab following the initiation of corticosteroid therapy for patients with COVID-19 (2022)
  • Author(s): Kawamata Takaya、Tanino Yoshinori、Nikaido Takefumi、Minemura Hiroyuki、Sato Yuki、Togawa Ryuichi、Watanabe Natsumi、Yamada Ryuki、Sato Riko、Onuma Takumi、Tomita Hikaru、Saito Mikako、Rikimaru Mami、Suzuki Yasuhito、Tsukada Yasuhiko、Nakamura Kiwamu、Kanemitsu Keiji、Iseki Ken、Shibata Yoko
  • Journal Title: Journal of Infection and Chemotherapy Volume: 28 Pages: 1639～1644
  • DOI: 10.1016/j.jiac.2022.08.021
  • Peer Reviewed
• [Journal Article] Usefulness of diurnal variation of fractional exhaled nitric oxide for predicting early therapeutic response to asthma treatment (2022)
  • Author(s): Uematsu, Manabu、et al.
  • Journal Title: Journal of Asthma Volume: 59 Pages: 2039～2050
  • DOI: 10.1080/02770903.2021.1984524
  • Peer Reviewed
• [Journal Article] Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic (2022)
  • Author(s): Suzuki Yasuhito、Shibata Yoko、Minemura Hiroyuki、Nikaido Takefumi、Tanino Yoshinori、et al.
  • Journal Title: International Journal of Medical Sciences Volume: 19 Pages: 834～841
  • DOI: 10.7150/ijms.71132
  • Peer Reviewed / Open Access
• [Journal Article] Lee Ho, et al. (2022)
  • Author(s): Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
  • Journal Title: BMC Infectious Diseases Volume: 22 Pages: 935
  • DOI: 10.1186/s12879-022-07927-w
  • Peer Reviewed / Open Access
• [Presentation] 間質性肺炎における抗Trichosporon asahii抗体の臨床的意義の検討 (2022)
  • Author(s): 河俣貴也，谷野功典, 二階堂雄文, 佐藤佑樹, 東川隆一, 渡邉菜摘, 山田龍輝, 佐藤理子, 冨田ひかる, 斉藤美加子, 力丸真美, 梅田隆志, 森本樹里亜, 鈴木康仁, 峯村浩之, 斎藤純平, 金沢賢也，柴田 陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 特発性肺線維症に対するnintedanib低用量の効果の検討 (2022)
  • Author(s): 渡邉菜摘, 谷野功典, 二階堂雄文, 佐藤佑樹, 東川隆一, 河俣貴也, 福原奈緒子, 山田龍輝, 佐藤理子, 大沼巧, 梅田隆志, 力丸真美, 森本樹里亜, 鈴木康仁, 峯村浩之, 斎藤純平, 金沢賢也，柴田 陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 睡眠時無呼吸症候群を合併した特発性肺線維症患者の臨床的特徴 (2022)
  • Author(s): 東川隆一、谷野功典、二階堂雄文、佐藤佑樹、河俣貴也、渡邉菜摘、山田龍輝、佐藤理子、大沼巧、梅田隆志、力丸真美、森本樹里亜、鈴木康仁、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 特発性間質性肺炎における末梢血単球数の予後予測バイオマーカーとしての検討 (2022)
  • Author(s): 佐藤佑樹、谷野功典、二階堂雄文、東川隆一、河俣貴也、渡邉菜摘、福原奈緒子、佐藤理子、山田龍輝、大沼巧、梅田隆志、力丸真美、森本樹里亜、鈴木康仁、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] HMGB1 fragmentsはPoly(I:C)誘導性急性肺炎を抑制する (2022)
  • Author(s): 二階堂雄文、谷野功典、王新涛、佐藤佑樹、東川隆一、河俣貴也、峯村浩之、玉井克人、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] Efficacy of Low-Dose Nintedanib in Idiopathic Pulmonary Fibrosis, a retrospective single institute analysis (2022)
  • Author(s): Natsumi Watanabe, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Takaya Kawamaya, Naoko Fukuhara, Tomoyoshi Lee Tomoyoshi, Riko Sato, Takumi Onuma, Mikako Saito, Hikaru Tomita, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Synthesized HMGB1 peptide attenuates Poly(I:C)-induced lung inflammation in mice (2022)
  • Author(s): Takefumi Nikaido, Tanino Yoshinori, Xintao Wang, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Katsuto Tamai, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Clinical Significance of Sleep Apnea Syndrome in Patients with Idiopathic Pulmonary Fibrosis (2022)
  • Author(s): Ryuichi Togawa, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Takaya Kawamata, Natsumi Watanabe, Naoko Fukuhara, Tomoyoshi Lee, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Peripheral blood monocyte count as a prognostic biomarker in idiopathic interstitial pneumonia other than idiopathic pulmonary fibrosis (2022)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Naoko Fukuhara, Lee Tomoyoshi, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Importance of clinical history of antigen exposure and anti-Trichosporon asahii antibody evaluation for diagnosis of summer-type hypersensitivity pneumonitis in patients with chronic interstitial lung diseases (2022)
  • Author(s): Takaya Kawamata, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Natsumi Watanabe, Naoko Fukuhara, Tomoyoshi Lee, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Book] Interstitial Lung Disease: From Diagnosis to Treatment (2022)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Xintao Wang, Yoko Shibata
  • Total Pages: 12
  • Publisher: Nova Science Publishers, Inc