2022 Fiscal Year Final Research Report
Elucidation of the Role of Connexin 43 in Ischemic Acute Renal Failure
Project/Area Number |
19K08684
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Tohoku Medical and Pharmaceutical University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 腎虚血・再灌流障害 / 急性腎障害 / ギャップ結合 |
Outline of Final Research Achievements |
In this study, we were able to demonstrate that connexin 43 plays an important role in the mechanism of renal ischemia-reperfusion injury, which is a major mechanism involved in significant diseases in the field of nephrology, such as acute kidney injury and late transplant kidney function disorder in kidney transplantation. We have clarified how this molecule is involved in the changes in the expression of genes, leading to the onset of the disease.
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Free Research Field |
腎臓内科学
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Academic Significance and Societal Importance of the Research Achievements |
腎虚血再灌流障害の発症する機序に関してconnexin 43の役割を明らかにすることができたため、急性腎障害や腎移植における後期移植腎機能障害など、腎臓内科領域において重要な疾患の治療法・予防法の開発につながることが期待できる。
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