2021 Fiscal Year Final Research Report

Development of leukocytes and endothelial cell-derived biomarkers for glomerular endothelial injuries

Research Project

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Project/Area Number	19K08739
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53040:Nephrology-related
Research Institution	Fujita Health University
Principal Investigator	Tsuboi Naotake 藤田医科大学, 医学部, 教授 (50566958)
Co-Investigator(Kenkyū-buntansha)	湯澤由紀夫藤田医科大学, 医学部, 教授 (00191479) 丸山彰一名古屋大学, 医学系研究科, 教授 (10362253) 林宏樹藤田医科大学, 医学部, 准教授 (10378086) 勝野敬之愛知医科大学, 医学部, 准教授 (60642337)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	抗好中球細胞質抗体 / 血管炎 / 血栓性微小血管障害症 / 白血球 / 血管内皮細胞 / バイオマーカー / 接着因子
Outline of Final Research Achievements	In the current study, we investigated the associations of urinary CD11b (U-CD11b) and CD163 (U-CD163) from ANCA-vasculitis patients with histological findings, proteinuria, kidney function, and kidney prognosis. Both of U-CD11b and U-CD163 were significantly elevated in patients with crescentic category, and were significantly correlated with crescentic formation rate and with intraglomerular accumulations of leukocytes presenting CD11b and CD163. U-CD163 level at diagnosis was increased in patient groups with low response to the immunosuppressive therapy or with renal functional impairments after the 6 months. However, multivariant analysis demonstrated that neither U-CD11b nor U-CD163 at diagnosis associated with eGFR slope.
Free Research Field	腎臓内科学
Academic Significance and Societal Importance of the Research Achievements	本研究成果から、尿中CD11b、CD163両者は、ANCA関連腎炎の糸球体炎症、特に白血球の集積を反映する有用なバイオマーカーであることが示唆された。ANCA関連腎炎は短期間に重篤な経過を示すことの多い疾患であるため、測定時間が短く、非侵襲的に腎組織所見を推測できる本検査法は、組織診断が躊躇される高齢者や状態の悪化した患者、出血のリスクが高い患者、あるいは組織診断体制が整っていない発展途上国においても臨床的価値が高いと考えられる。