Role of STAP proteins in allogeneic hematopoietic stem cell transplantation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Osaka University
• Principal Investigator: Saitoh Hideaki 大阪大学, 医学部附属病院, 医員 (50815496)
• Co-Investigator(Kenkyū-buntansha): 一井 倫子 大阪大学, 医学系研究科, 助教 (30633010) ; 柴山 浩彦 大阪大学, 医学系研究科, 招へい教授 (60346202) ; 戸田 淳 大阪大学, 医学部附属病院, 医員 (90770834)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 同種造血幹細胞移植 / GVHD

Outline of Final Research Achievements

Signal-transducing adaptor protein (STAP) family regulates various intracellular signaling pathways with a pleckstrin homology domain in the N-terminal region and SRC-homology 2-like domain. Following the elucidation of the effects of STAPs on terminally differentiated immune cells, such as macrophages, T cells, mast cells, and basophils, recent findings have shown the critical roles of STAP-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this study, we evaluated the effects of STAPs on immune-reconstitution and immune responses after allogeneic hematopoietic stem cell transplantation.

Free Research Field

血液内科

Academic Significance and Societal Importance of the Research Achievements

同種造血幹細胞移植は、難治性白血病や重症の造血不全疾患などで唯一治癒が期待できる治療法であるが、移植後のGVHDや免疫不全のよる易感染性の制御が難しく、未だに高い致死リスクが存在する。本研究は生体の免疫再構築機構と移植後のGVHD発症にSTAP-2が作用する事を明らかにし、治療標的となる可能性を示した。