Study of the regulatory mechanisms of hematopoietic stem cell homeostasis mediated by alterations in the nutritional environment

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kanazawa University
• Principal Investigator: TADOKORO Yuko 金沢大学, がん進展制御研究所, 助教 (00447343)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 幹細胞 / 自己複製

Outline of Final Research Achievements

An excessively unbalanced diet is one of the causes of obesity and lifestyle diseases. In this study, we aim to elucidate the regulatory mechanisms of hematopoietic stem cell (HSC) homeostasis mediated by gut microbiota-derived metabolites, which are altered by dietary habits. We have found that a gut microbiota-derived metabolite induced by a high-fat diet feeding suppresses the HSC functions. Furthermore, we have shown that a gut microbiota-derived metabolite induced by high-dietary fiber diet feeding enhances the HSC functions. Our findings may contribute to development of prevention and treatment improvement of leukemogenesis and lifestyle diseases caused by diet-induced hematopoietic abnormalities.

Free Research Field

幹細胞生物学

Academic Significance and Societal Importance of the Research Achievements

食生活の異常は肥満や生活習慣病などの原因となるが、造血幹細胞に対する影響については十分理解されていない。本研究成果においては、食餌による腸内細菌由来代謝産物の変化が造血幹細胞の機能制御に影響することを見出した点において学術的重要性がある。このような代謝物の機能は種を超えて共通性を示すことが考えられることから、本研究成果は幹細胞機能の制御機構を理解する上で重要な知見である。造血異常は白血病発症や様々な加齢性疾患の発症にも関わることから、食生活と造血異常に起因する疾患との関係を考える上で本研究成果の社会的意義は大きいと考えられる。