2021 Fiscal Year Final Research Report
Identification and functional analysis of pathogenic fibroblasts in atopic dermatitis
| Project/Area Number |
19K08912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
出原 賢治 佐賀大学, 医学部, 教授 (00270463)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | アトピー性皮膚炎 / 線維芽細胞 / ペリオスチン |
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| Outline of Final Research Achievements |
In this study, we focused on the diversity of fibroblasts and aimed to identify pathological fibroblasts and their functions in atopic dermatitis. We found that some fibroblasts in both the experimental atopic dermatitis model using MC903 and the spontaneous atopic dermatitis model using FADS mice have a population that expresses periostin at high levels. Furthermore, we generated periostin-deficient FADS mice and performed functional analysis. Herein, we showed that periostin-deficient FADS mice exhibited reduced dermatitis and itch-scratch behavior.
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| Free Research Field |
:膠原病およびアレルギー内科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、ペリオスチンを高発現する一部の線維芽細胞が今回アトピー性皮膚炎の病態形成にかかわる細胞であることを明らかにするとともに、皮膚炎や掻痒において重要な役割を担っていることを明らかにした．本研究の成果は、ペリオスチンあるいはペリオススチンを発現する線維芽細胞がアトピー性皮膚炎の皮膚炎やかゆみーひっかき行動の新たな治療戦略の基盤構築につながるものである．
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