2023 Fiscal Year Final Research Report
Elucidation of the factors contributing to its increase and resistance to antimicrobial drugs in pulmonary MAC disease
| Project/Area Number |
19K08966
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 肺Mycobacterium avium症 / 薬剤抵抗性 / 増加要因 / ゲノム解析 |
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| Outline of Final Research Achievements |
To investigate the resistance of Mycobacterium avium to antimicrobial drugs and the factors contributing to its increase in Japan, we compared the drug susceptibility and genome of various clinical isolates. Our analysis showed that strains derived from patients with pulmonary M. avium disease showed higher resistance to various antibiotics, including clarithromycin, than strains derived from patients with systemically disseminated M. avium disease and strains derived from pigs. Furthermore, comparative genome analysis showed that three different derived strains formed different clusters, and the pMAH135 plasmid was present in a specific gene region of the strain derived from pulmonary M. avium disease. These results suggest that pMAH135 is involved in not only resistance to antimicrobial drugs but also a factor contributing to the increase of pulmonary M. avium disease in Japan.
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| Free Research Field |
感染症
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| Academic Significance and Societal Importance of the Research Achievements |
肺M. avium症の臨床上の問題点として，抗菌薬に対する治療抵抗性や罹患率の増加が挙げられ，その要因の一つはM. aviumの抗菌薬に対する抵抗性（低感受性）や耐性の獲得である。しかし，それらのメカニズムや罹患率の増加の要因については不明である。
本研究課題により得られた研究成果により，上記問題点の要因を決定している病原体側の遺伝学的特性や特定遺伝子の存在が明らかになり，肺M. avium症の問題点の解明に大きく寄与することができた。これらの知見は，本感染症の治療において重要な情報となり，学術的・社会的意義は大きいと考える。
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