The regulation of excise and energy metabolism by Pin1 in skeletal muscle

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K08982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Hiroshima University
• Principal Investigator: Nakatsu Yusuke 広島大学, 医系科学研究科(医), 准教授 (20452584)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: Pin1 / 骨格筋 / 運動 / 糖代謝

Outline of Final Research Achievements

Prolyl isomerase Pin1 associates with substrates through the motif containing pSer/pThr-Pro, and regulates the functions. In this study, we examined the roles of Pin1 in skeletal muscle on exercise or energy metabolism. In high fat diet feeding, skeletal muscle specific Pin1 KO mice show the exacerbation of obesity, compared to wild type mice. In addition, Pin1 KO mice revealed the insulin resistance and the lower capacity of excise. These phenomena may be caused by the changes of thermogenesis or the upregulation of Foxo1.
In conclusion, Pin1 in skeletal muscle is deeply committed to excise and glucose metabolism.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

骨格筋の機能低下は、糖尿病等の生活習慣病につながることが知られており、また、近年、筋重量や筋機能が低下するフレイルやサルコペニアが社会問題となっている。本研究により、骨格筋のPin1は、筋重量や筋線維の割合に影響を与えずに、糖代謝やエネルギー代謝を調節することが明らかとなった。そのメカニズムを解明することで、筋重量非依存的な糖代謝調節機構が明らかになると考えられる。