2021 Fiscal Year Final Research Report
A study the possibilities that extracellular vesicles from muscle cells obtained by stretching stimulation can be a new target for improving glucose metabolism.
| Project/Area Number |
19K08993
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 細胞外小胞 / 骨格筋 / 糖取り込み / 伸展刺激 |
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| Outline of Final Research Achievements |
We found that the extracellular vesicles (EVs) secreted by stretch stimulation from skeletal muscle cells improve glucose uptake in adipocytes. The mechanism is that EVS are directly taken up into adipocytes and carry the protein and miRNA, which are related to glucose uptake.
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| Free Research Field |
糖代謝
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| Academic Significance and Societal Importance of the Research Achievements |
骨格筋が収縮する運動が糖代謝改善作用があることは周知の通りであり、骨格筋量や機能が低下している高齢者、糖尿病・肥満症患者における糖尿病治療を困難にしている。骨格筋の伸展刺激により分泌される細胞外小胞（EVs）が生体内での糖代謝改善作用を有することが明らかとなれば、新たな糖尿病治療に繋がり、超高齢化社会を迎える日本での糖尿病予防・治療に貢献するものと考える。
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