Noninvasive diagnoses for malignant neuroendocrine neoplasms

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Kudo Atsushi 東京医科歯科大学, 東京医科歯科大学病院, 准教授 (20376734)
• Co-Investigator(Kenkyū-buntansha): 田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420) ; 田邉 稔 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 転移能

Outline of Final Research Achievements

Comprehensive gene analysis was performed as a test study in 10 non-simple nodule type cases and 10 simple nodule type cases, and gene set enrichment analysis (GSEA) was performed. The protein expression of the obtained target gene was immunostained. Currently, 50 samples have been collected and are being reanalyzed. The pathophysiological significance of sugar chain marker expression was examined. The number of PAX6 test cases was increased to about 200. Accumulation of data for new non-invasive indicators. The validation study for macroscopic classification, along with the prospective data accumulated at the TRI Medical Innovation Center, is investigating the impact of macroscopic classification on prognosis.

Free Research Field

外科学一般および小児外科学関連

Academic Significance and Societal Importance of the Research Achievements

膵神経内分泌腫瘍には病理学的、あるいは画像診断学的に予後の悪い腫瘍の肉眼分類がある。非単純結節型と単純結節型の分子学的特徴を導くことで、一時独立に行った糖鎖マーカー発現のメカニズムとの関係が明らかにできる可能性がある。糖鎖マーカーの解析では予後を決定するメカニズムが新たに発見できた。分子生物学的な特徴と病理学的肉眼所見、画像診断学的所見をつなぐことができ、新しい非侵襲的指標の作成が可能になった。